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  • Title: Effect of estrogen replacement therapy on lipids. Implications for cardiovascular risk.
    Author: LaRosa JC.
    Journal: J Reprod Med; 1985 Oct; 30(10 Suppl):811-3. PubMed ID: 4078813.
    Abstract:
    Estrogen administration lowers low-density-lipoprotein cholesterol levels and raises high-density-lipoprotein cholesterol levels; those effects are associated with a diminished risk of atherosclerotic cardiovascular disease. Because of adverse effects on the endometrium, estrogen is commonly given in combination with a progestogen. Progestogens have adverse effects on plasma lipoproteins, though, and the beneficial effects of estrogen may be neutralized when a progestogen is added. Data on lipoprotein effects of hormone replacement therapy in postmenopausal women are scarce, and further study is needed.
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