These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Induction of 6-thioguanine resistance, chromosome aberrations and SCE by dinitropyrenes in Chinese hamster ovary cells in vitro.
    Author: Edgar DH, Brooker PC.
    Journal: Mutat Res; 1985 Dec; 158(3):209-15. PubMed ID: 4079952.
    Abstract:
    The ability of Chinese hamster ovary (CHO) cells to convert dinitropyrenes (DNPs) to mutagenic species has been investigated by examining the effects of 1,6-DNP and 1,8-DNP on three distinct end-points in this cell line. At concentrations ranging from 0.05 to 5 micrograms/ml both analogues induced increases in the frequency of 6-thioguanine-resistant mutants in CHO cells when exposure was limited to 3 h. This treatment time was also sufficient to permit the induction of sister-chromatid exchange and chromosome aberrations in CHO cells. The results obtained suggest that CHO cells, unlike mouse lymphoma L5178Y cells, possess an endogenous metabolic activity which is capable of bringing about the conversion of DNPs to their mutagenic form without a requirement for prolonged exposure periods and as such may be a more suitable cell line for the study of this class of compounds.
    [Abstract] [Full Text] [Related] [New Search]