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  • Title: Reaction products of dimethyl sulfoxide with 5,5-disubstituted barbituric acids and their biological properties.
    Author: Czuba W, Kasperek L, Prelicz D, Borkowska B, Bogdal M, Krzywosiński L, Przemyk B.
    Journal: Pol J Pharmacol Pharm; 1985; 37(4):533-40. PubMed ID: 4080647.
    Abstract:
    In the reaction of 5,5-disubstituted barbituric acids 1-5 with DMSO mixtures of compounds with one (6, 8, 10, 12) or two methylthiomethyl groups (7, 9, 11, 13) at one or both nitrogen atom are formed. Some of obtained compounds were screened for their central action namely anticonvulsant activity.
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