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  • Title: [Electrophysiogical and neuropharmacological studies in a patient with progressive myoclonus-epilepsy (author's transl)].
    Author: Rumpl E, Gerstenbrand F, Hengl W, Binder H.
    Journal: EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb; 1977 Jun; 8(2):77-81. PubMed ID: 408123.
    Abstract:
    A progressive form of myoclonus-epilepsy was described in an 21 year old girl. Electrophysiological and neuropharmacological studies were carried out. The typical EEG-pattern, the close association of cortical discharges and myoclonic jerks, the form of myoclonus indicated a "pyramidal" myoclonus. Pharmacological data suggested that two possible mechanisms--a partial deafferentation of cortical neurones and a failure of thalamic, extrapyramidal and brain stem reticular formations--might be responsible for the EEG-abnormalities and concomitant myoclonus. Results from neuropharmacological studies demonstrated a suppressive effect (on EEG-discharges and myoclonic jerks) of clonazepam, diazepam, phenobarbital, taurine, levodopa and budipin. Taurine, levodopa and budipin might induce a new aspect in therapy of progressive myoclonus epilepsy and of myoclonus caused by other etiologic factors.
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