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  • Title: Rifampicin-induced renal failure.
    Author: Cohn JR, Fye DL, Sills JM, Francos GC.
    Journal: Tubercle; 1985 Dec; 66(4):289-93. PubMed ID: 4082283.
    Abstract:
    Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy. The following is a report of 2 cases of rifampicin-induced renal insufficiency. In the first case oligo-anuric renal failure occurred on the thirteenth day of treatment, after the patient had taken only 9 doses of medication. The second case occurred in a patient who developed renal failure while on daily therapy in the hospital. A literature review revealed 83 other reported cases of rifampicin-induced renal insufficiency. Intermittent or interrupted therapy appears to be a significant risk factor for the development of this complication.
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