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  • Title: Retinal ultrastructure of neuronal ceroid-lipofuscinosis in the dalmatian dog.
    Author: Goebel HH, Dahme E.
    Journal: Acta Neuropathol; 1985; 68(3):224-9. PubMed ID: 4082925.
    Abstract:
    Ultrastructural studies of the retinae in two NCL-affected Dalmatian dogs revealed ubiquitous accumulation of lipopigments in numerous cell types of the retina, the fine structure of which closely resembled that seen in NCL-affected English setters. Photoreceptors and other retinal cell types were largely intact. These findings show that the retinal involvement in NCL of our Dalmatian dogs is identical to that of NCL-affected English setters. It also shows that in canine NCL a severe retinopathy, regularly encountered in human childhood NCL, does not develop. Thus, the NCL of Dalmatian dogs--and English setters--represents a reliable model to study human NCL, but for human retinopathia pigmentosa perhaps only at its earliest stage.
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