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  • Title: Inhibition of 2-oxoglutarate oxidation in plant mitochondria by pyruvate.
    Author: Dry IB, Wiskich JT.
    Journal: Biochem Biophys Res Commun; 1985 Dec 17; 133(2):397-403. PubMed ID: 4084285.
    Abstract:
    Oxidation of 2-oxoglutarate (in the presence of malonate) by mitochondria isolated from turnip, pea leaf and cauliflower tissue was dramatically inhibited by micromolar concentrations of pyruvate. Pyruvate, however, had little or no effect on 2-OG oxidation when carried out in the absence of malonate. The inhibition was reversed by alpha-cyano-4-hydroxycinnamic acid, indicating pyruvate uptake into the matrix was required for the inhibitory effect. In contrast, pyruvate had no effect on 2-oxoglutarate oxidation by mitochondria isolated from rat heart. The possible significance of the effect in terms of the control of 2-oxoglutarate dehydrogenase activity during the operation of a malate/aspartate shuttle in plant mitochondria is discussed.
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