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  • Title: Evidence that transcription of the hexokinase gene is increased in a rapidly growing rat hepatoma.
    Author: Johansson T, Berrez JM, Nelson BD.
    Journal: Biochem Biophys Res Commun; 1985 Dec 17; 133(2):608-13. PubMed ID: 4084289.
    Abstract:
    The level of hexokinase-specific mRNA in rat liver and in rat ascites hepatoma (Zajdela) was assessed by translating free polysomes from both cell types in a reticulocyte lysate. Translation of hexokinase occurred with approximately a 10 fold higher frequency in tumor cells than in liver, suggesting that transcriptional activation is in part responsible for increased levels of hexokinase in tumor.
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