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  • Title: Subendothelial accumulation of unesterified cholesterol. An early event in atherosclerotic lesion development.
    Author: Kruth HS.
    Journal: Atherosclerosis; 1985 Nov; 57(2-3):337-41. PubMed ID: 4084363.
    Abstract:
    This preliminary report describes the simplest and possibly earliest lipid-containing lesions induced in aortas of rabbits fed a cholesterol-containing diet. Subendothelial accumulation of unesterified cholesterol, detected with filipin dye, appears to precede morphologic changes in endothelium and accumulation of subendothelial lipid-containing "foam" cells. The origin of subendothelial unesterified cholesterol remains to be determined.
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