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  • Title: [Specificity of cytochrome P-450 isoforms contained in endoplasmic reticulum membranes and nuclear membranes in relation to benzo(a)pyrene].
    Author: Sergeev BL, Karamysheva AF, Kobliakov VA.
    Journal: Eksp Onkol; 1985; 7(6):30-4. PubMed ID: 4085395.
    Abstract:
    The metabolic activation of benz(a)pyrene (BP) catalyzed by rat liver microsomes and isolated liver nuclei in the presence of certain inhibitors of the monooxygenase system was studied. Several forms of cytochrome P-450 are supposed to participate in metabolic conversion of BP. The specificity of cytochrome P-450 isoforms contained in the endoplasmic reticulum and in nuclear membranes is discussed.
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