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  • Title: [Comparative analysis of the changes in myocardial electrical and contractile activity in rats exposed to rubomycin and its nitroxyl derivative].
    Author: Vasilets LA, Guseva TI, Mokh VP.
    Journal: Farmakol Toksikol; 1985; 48(6):33-7. PubMed ID: 4085626.
    Abstract:
    A comparative analysis was performed of changes in the contractile and electrical activity of the rat myocardium in experiments on isolated papillary muscles, obtained 2-2.5 months after the discontinuation of chronic administration of rubomicin in 0.7 mg/kg and ruboxil in 3 mg/kg dose to the animals. It is shown that rubomicin decreases the maximal rate of growth of the anterior potential of action and in a greater degree than ruboxil inhibits the contractile activity of papillary muscles. The preparations had a contrary influence on the rhythmoinotropic relations in the rat myocardium. This difference might be connected with the ability of rumobimicin to block and of ruboxil to stimulate Na-Ca metabolism. The participation of these mechanisms in the process of development of cardiotoxicity of antracycline antibiotics is discussed.
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