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  • Title: [Effect of folic acid and methotrexate on the function of the hydroxylating system and the cholesterol and phospholipid content in the liver microsomes of rats].
    Author: Lukienko PI, Bushma MI, Legon'kova LF, Abakimov GZ.
    Journal: Farmakol Toksikol; 1985; 48(6):53-5. PubMed ID: 4085631.
    Abstract:
    Folic acid and its antivitamin methotrexate exert contrary actions on the activity of monooxygenases of the rat liver endoplasmatic membranes. Under the influence of folic acid (intra-abdominally, 100 mg/kg-6 days, 25 mg/k-14 days) there is a growth in the B5 and P-450 cytochrome content, NADP.H-cytochrome P-450 and NAD.H-cytochrome B5-reductase activity and in the oxidation rate of NADP.H, NAD.H and ethylmorphine N-demethylation. In similar experimental conditions, methotrexate (subcutaneously 0.25 and 1 mg/kg for 6 days, 0.25 mg/kg for 14 days) decreases the rate of NAD.H and NADP.H oxidation and NAD.H-cytochrome B5-reductase activity, the content of cytochromes B5 and P-450 and the binding degree of the latter with ethylmorphine, aniline and their metabolic rate. A decrease of the dose of the agents with a simultaneous increase of the time of administration enhances the vitamin action and reduces that of the antivitamin.
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