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  • Title: New cytotoxic guaianolides and derivatives from Grosheimia macrocephala.
    Author: Barbetti P, Fardella G, Chiappini I, Scarcia V, Candiani AF.
    Journal: Farmaco Sci; 1985 Oct; 40(10):755-69. PubMed ID: 4085640.
    Abstract:
    Grosheimia macrocephala (Compositae) proved to be a very interesting natural source, not only of grosheimin (I), but also of cynaropicrin (III). Some derivatives from these two natural sesquiterpene gamma-lactones were prepared (Schemes 2 and 3) and two new natural guaianolides: 4'-deoxy-cynaropicrin (V) and 4'-nor-2'-metoxy-cynaropicrin (VI) were isolated and structurally identified. A series of these compounds were submitted to in vitro preliminary testing of cytostatic activity against KB cell lines and relationships between bioactivity and chemical features were investigated.
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