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  • Title: The premenstrual syndrome: selection of women for treatment trials.
    Author: Metcalf MG, Hudson SM.
    Journal: J Psychosom Res; 1985; 29(6):631-8. PubMed ID: 4087229.
    Abstract:
    Statements made at interview by 31 women presenting with the premenstrual syndrome (PMS) were compared with the moods and physical symptoms reported daily during the next 6 menstrual cycles. Diagnosis was confirmed in 21 women (premenstrual tension (PMT) present in greater than or equal to 5/6 cycles), not substantiated in two (PMT in less than or equal to 1/6 cycles) and in doubt in eight. Placebo treatment was associated with a significant over-all reduction in both the incidence and the severity of mood-related PMT, but had no clear effect on premenstrual physical symptoms; women with PMT in 5 cycles were usually placebo-resistant. Criteria are proposed for the selection of women for treatment trials based on their response to placebo.
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