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  • Title: Effect of di-n-propylacetate on the 'binding of GABA to synaptosome-enriched fraction of rat cerebral cortex.
    Author: Kulig BM, Gonzalez-Portal C, Somoza E, Defeudis FV.
    Journal: Psychopharmacology (Berl); 1977 Aug 16; 53(3):255-7. PubMed ID: 408853.
    Abstract:
    The effect of di-n-propylacetate (DPA) on the 'binding' of gamma-aminobutyric acid (GABA) to a synaptosome-enriched fraction of rat cerebral cortex has been examined using differential centrifugation and double-isotope liquid scintillation spectrometry. DPA at 10(-4) M caused a slight decrease in GABA binding. This effect could explain in part the in vivo anticonvulsant and behavioral effects of this drug when administered to animals in high systemic doses.
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