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  • Title: Salt induced conformational transition between A and Z forms of r(CGCGCG) as revealed by a Raman spectroscopic study.
    Author: Nishimura Y, Tsuboi M, Uesugi S, Ohkubo M, Ikehara M.
    Journal: Nucleic Acids Symp Ser; 1985; (16):25-8. PubMed ID: 4088878.
    Abstract:
    Solution conformation in different conditions of r(CGCGCG) has been studied by a Raman spectroscopic method. In NaCl solution, r (CGCGCG) takes only an A-form duplex in which guanosine and cytidine have C3'endo-anti conformation even at 5M salt concentration. In much higher ionic strength condition (5M NaCl plus 1M MgCl2 or 6M NaClO4), it undergoes a transition to a left-handed Z-form. The Raman spectrum of the Z-form RNA was found to be very similar to that of Z-form DNA, suggesting that Z-RNA involves a C3'endo-syn guanosine and an in between form of C2'endo-Cl'exo-anti cytidine.
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