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  • Title: Dexamethasone suppression test in predicting response to tricyclic antidepressants in depressed outpatients.
    Author: Peselow ED, Goldring N, Barouche F, Fieve RR.
    Journal: Psychopathology; 1985; 18(4):206-11. PubMed ID: 4089119.
    Abstract:
    75 outpatients who presented to an affective disorder clinic received the dexamethasone suppression test (DST). Following 1 week observation, and following 1 week on low-dose imipramine HCl, all patients who remained depressed (Hamilton score 16 or greater) were given a full clinical trial of imipramine HCl (150-300 mg/day) over a minimum 3- to 5-week period. Of the 45 patients who required this trial and who received imipramine HCl for at least 3 weeks, there was no relationship between DST suppression or nonsuppression vs. clinical response to imipramine HCl. There was a statistically significant trend for suppressors (negative DST) to respond either spontaneously or to low-dose imipramine HCl as opposed to nonsuppressors (positive DST).
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