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  • Title: S-adenosyl-L-methionine protection against alpha-naphthylisothiocyanate-induced cholestasis in the rat.
    Author: Di Padova C, Di Padova F, Tritapepe R, Stramentinoli G.
    Journal: Toxicol Lett; 1985 Dec; 29(2-3):131-6. PubMed ID: 4089881.
    Abstract:
    The effect of S-adenosyl-L-methionine (SAMe) on cholestasis induced by alpha-naphthylisothiocyanate (ANIT) was studied in rats. SAMe significantly attenuated both bile flow impairment and elevated values of serum bilirubin, glutamic pyruvic transaminase and alkaline phosphatase in ANIT-treated animals. These results suggest that SAMe protects the rat liver against the toxic effects of ANIT.
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