These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Acute effects of sublingual nifedipine on segmental and global left ventricular function in coronary artery disease; an angiographic study.
    Author: Pust B, Obrez I.
    Journal: Z Kardiol; 1985 Nov; 74(11):633-8. PubMed ID: 4090579.
    Abstract:
    In 12 patients with significant coronary artery disease (CAD) segmental and global left ventricular (LV) function was studied by quantitative cineventriculography before and 5 min after sublingual administration of 20 mg nifedipine (N). Significant increase of mean relative hemiaxes shortening of inferior (24 +/- 10%----38 +/- 13%) and apical (31 +/- 10%----42 +/- 14%) wall segments, as well as improvement of ejection fraction (61 +/- 14%----75 +/- 14%), mean circumferential fiber shortening velocity (1.05 +/- 0.46 ccf/s----1.41 +/- 0.47 ccf/s) and end-systolic volume (57 +/- 26 ml----37 +/- 27 ml) of the LV were found after administration of N. The highest increase of segmental contraction (28 +/- 11%----44 +/- 16%; p less than 0.001) was noted in 20 noninfarcted wall segments, perfused by significantly stenosed coronary arteries. No significant improvement could be detected in 6 infarcted segments. A second group consisting of 12 patients with CAD showed a significant reduction of the aortic end-diastolic pressure (89 +/- 9 mm Hg----79 +/- 7 mm Hg; p less than 0.001) but no significant change of isovolumic contractility indices and heart rate was observed after N administration. The study suggests that acute improvement of LV function, found 5 min after sublingual administration of N, is mainly due to improved contraction of ischemic myocardial wall segments. Among different possible reasons for this improvement LV afterload reduction after N administration seems to be the most important one.
    [Abstract] [Full Text] [Related] [New Search]