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  • Title: [Stages in the development of neuroses in the dog and effects of preparations with antidepressive and tranquilizing properties].
    Author: Mekhedova AIa, Kozlovskaia MM, Neznamov GG, Nikuradze VO.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1985; 35(6):1147-55. PubMed ID: 4090731.
    Abstract:
    In modelling of neuroses, successive stages of development of this pathology were observed in dogs. The first stage is characterized by circular disturbances of conditioned activity, vegetative shifts of compensatory character and intensification of individual characteristics of behaviour. At the second stage, parallel with sharp disturbances of conditioned reflexes and with vegetative dystonia, a distortion of emotional reactions was observed in dogs. It is essential that resumption of neurotization episodes in experiments on dogs with the second stage of disease promoted a development of depressive-like states. Diazepam corrected the behavioural and vegetative shifts at the first stage of neurosis. Non-typical antidepressants eliminated the manifestation of symptoms complex of the disease, especially at prolonged treatment.
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