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  • Title: Freeze-dried vaccine against Rinderpest: stability and activity study.
    Author: Languet B, Precausta P, Mackowiak M, Dubourget P, Reynaud G, Duret C.
    Journal: Comp Immunol Microbiol Infect Dis; 1985; 8(3-4):285-95. PubMed ID: 4092427.
    Abstract:
    A freeze-dried vaccine against Rinderpest was prepared from modified virus multiplied in calf kidney cell culture. Characteristics of the vaccine are as follows: high titre after freeze-drying (10(4) CCID50/dose), well-adapted freeze-drying stabilizer which ensures maintenance of the infective titre of the vaccinal virus, even under severe conditions (3.5 days at +45 degrees C), use of an appropriate solvent: magnesium sulphate molar solution or more simply physiological saline (for stability after reconstitution even at high temperatures--up to 4 h at +45 degrees C). The activity of the vaccine, tested in cattle by antibody titration and resistance to specific challenge perfectly satisfies requirements set by the WHO and OIE.
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