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  • Title: Effect of ovariectomy and estrogen on [3H]imipramine binding to different regions of rat brain.
    Author: Stockert M, De Robertis E.
    Journal: Eur J Pharmacol; 1985 Dec 17; 119(3):255-7. PubMed ID: 4092731.
    Abstract:
    In rats, 35 days after ovariectomy, the number of [3H]imipramine binding sites increased more than 200% in striatum, hippocampus and hypothalamus but it did not change in cerebral cortex and brain-stem. Estradiol-17 beta acting in vitro inhibited [3H]imipramine binding in control membranes of striatum, hippocampus and hypothalamus, but not in the same regions from ovariectomized rats.
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