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  • Title: The ultrastructure of liver cells in women under steroid therapy. II. Contraceptive therapy.
    Author: Martínez-Manautou J, Aznar-Ramos R, Bautista-O'Farrill J, González-Angulo A.
    Journal: Acta Endocrinol (Copenh); 1970 Oct; 65(2):207-21. PubMed ID: 4097029.
    Abstract:
    The fine structures of liver cells biopsies of 14 women using oral contraceptives and 8 women who were not using steroids were studied electron microscopically. In all the women studied, liver function and coagulation tests were normal. Women treated with microdoses of progestogens and with combinations of progestogens and estrogens showed dilation and vesiculation of both the rough and smooth endoplasmic reticulum. Women using sequential OC's showed more marked vesiculation. 5-10% of the mitochondria per cell of women using chlormadione and 20-40% of the mitochondria of women on combined or sequential therapy showed elongation and crystalloid inclusions in the mitochondrial matrices. Fatty degeneration was noted. This was more pronounced in women using combined and sequential OC's. The nucleus, Golgi-complex, bile canaliculi, and glycogen granules were all unmodified.
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