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  • Title: Effect of daily administration of 0.5 mg. of chlormadinone acetate on plasma levels of follicle-stimulating hormone, luteinizing hormone, and progesterone during the menstrual cycle.
    Author: Saunders DM, Marcus SL, Saxena BB, Beling CG, Connell EB.
    Journal: Fertil Steril; 1971 May; 22(5):332-44. PubMed ID: 4102481.
    Abstract:
    Investigators at Cornell University Medical College and New York Medical College in New York City studied the effects of chlormadinone acetate administration on hormone levels in an effort to better understand the contraceptive mode of action of this drug. 9 healthy women had 2 consecutive cycles studied. While the first cycle was a control cycle, the second one involved chlormadinone acetate administration, .5 mg/day from Day 1 to Day 28 or until the occurrence of spontaneous menstruation if this delayed until after Day 28. Basal body temperature was recorded each morning. Chlormadinone tended to suppress the mean luteinizing hormone and follicle stimulating hormone peaks and the plasma progesterone levels. 3 patients are believed to have ovulated during the experimental cycle, but probably in 2 of them the luteal phase was less pronounced than a normal luteal phase. However, 1 of the remaining 6 patients had failed to ovulate in the control cycle. Though limitations exist in the study of the parameters investigated here, such study is necessary since direct evidence of ovulation (e.g., pregnancy, observation of corpus luteum) is usually unobtainable.
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