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  • Title: Second trimester abortion with single intra-amniotic injection of prostaglandins E2 or F2 alpha.
    Author: Karim SM, Sharma SD.
    Journal: Lancet; 1971 Jul 03; 2(7714):47-8. PubMed ID: 4103691.
    Abstract:
    Intravenous infusion of prostaglandins (PG) for pregnancy termination has been associated with long duration of infusion and side effects (nausea, vomiting, diarrhea, and erythema at the site of injection). Some of these side effects have been eliminated through the use of intravaginal and intrauterine administration of PGs. The authors studied the effects of intraamniotic administration of PG on the 2nd trimester pregnant uterus based on the observations that PGE2 and F2alpha are found in samples of amniotic fluid obtained during spontaneous abortion. Single intraamniotic administration of 2.5-5.0 mg PGE2 or 25 mg PGF2alpha in 10 women 13-22 weeks pregnant stimulated uterine contraction and resulted in abortion in every case. 8 women had complete abortion and 2 necessitated manual removal of the placenta. Injection-abortion interval ranged from 4-1/2-18 hours, with a mean of 11.4 hours. 4 women experienced nausea and 3 had vomiting. There were no other side effects. This route of administration appears to produce a local action on the uterus, and the procedure does not require withdrawal of any amniotic fluid.
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