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  • Title: In vitro synthesis of immunoglobulin-A by salivary glands from animals of different species.
    Author: Hurlimann J, Darling H.
    Journal: Immunology; 1971 Jul; 21(1):101-11. PubMed ID: 4104287.
    Abstract:
    The in vitro synthesis of immunoglobulins by the salivary glands from eight different species was studied. It has been demonstrated that salivary glands from the cow, horse, sheep, pig, rat and guinea-pig preferentially synthesize a fast migrating immunoglobulin which seems to be analogous to IgA. In three of the species, the cow, sheep and pig, the IgA-like component cross-reacts with human IgA. The IgA synthesized by the salivary glands from the rat cross-reacts with the mouse IgA. When one compares the salivary IgA from the cow, horse, sheep, pig and rat with the IgA synthesized by the lymph nodes, there is evidence of additional antigenic determinants in the salivary IgA. These additional determinants could very possibly correspond to a secretory component. Thus, it appears that in most mammalian species there exists a mechanism for the synthesis of secretory IgA analogous to the one which exists in humans.
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