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  • Title: Effects of hormones on development and function of lymphoid tissues. II. Delayed development of immunological capacity in pituitary dwarf mice.
    Author: Baroni CD, Pesando PC, Bertoli G.
    Journal: Immunology; 1971 Sep; 21(3):455-61. PubMed ID: 4105471.
    Abstract:
    The present report describes the morphology of lymphoid tissues and the humoral antibody response during primary and secondary immune responses to sheep erythrocytes (SRBC) in Snell-Bagg hereditary pituitary dwarf mice. It has been found that while 19S primary response was depressed to a great extent, 7S secondary response reached practically normal levels. Histological studies of the peripheral lymphoid tissues have shown patterns of cellular depletion in nonthymus-dependent areas in dwarfs killed during primary response, while these areas appeared markedly cellular after a second antigenic stimulation. It is suggested that the cell systems involved in antibody production during primary and secondary responses to SRBC may be separate and different. As a result, the endocrine imbalance of the dwarf mice affects only the primary response to SRBC.
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