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  • Title: The immune response in the hamster. 3. Selective induction of concomitant antibody formation and unresponsiveness in the 7S 1 - and 7S 2 -globulins with soluble hen egg albumin.
    Author: Coe JE.
    Journal: Immunology; 1971 Aug; 21(2):175-91. PubMed ID: 4105900.
    Abstract:
    Synthesis of antibody to hen egg albumin (HEA) was restricted to one of the 7S immunoglobulins (7Sγ1-globulin) when hamsters were inoculated with soluble HEA (HEA—saline). This selective induction occurred regardless of the amount of HEA—saline injected (0.001–5.0 mg) or the route of inoculation. In contrast, HEA in Freund's adjuvants induced synthesis of anti-HEA in both the 7Sγ1- and 7Sγ2-globulins, even when as little as 0.1 μg of HEA was used. Repeated inoculations of hamsters with HEA—saline increased or maintained 7Sγ1-antibody, but did not induce anti-HEA synthesis in the 7Sγ2-globulins. The results of cell transfer experiments indicated that cells from HEA—saline treated hamsters were primed to synthesize 7Sγ1 anti-HEA and were specifically unresponsive for 7Sγ2 anti-HEA synthesis. Selective induction of antibody production and unresponsiveness, concomitantly, within different immunoglobulin classes suggests that different antibody induction mechanisms are utilized by these two immunoglobulin classes.
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