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  • Title: Mechanism of histamine release from perfused guinea-pig lung by soluble immune complexes. I. Complexes containing rabbit antibody.
    Author: Broder I, Taichman NS.
    Journal: Immunology; 1971 Aug; 21(2):193-205. PubMed ID: 4105901.
    Abstract:
    Histamine release and mast cell degranulation were induced in unsensitized perfused guinea-pig lung by the injection of soluble immune complexes containing rabbit antibody. This process was influenced by a number of different conditions in the same manner as the process activated by antigen in passively sensitized guinea-pig lung. The conditions studied included altered temperature, deprivation of calcium or magnesium, and addition to the perfusion fluid of maleate, succinate, iodoacetate, N-ethylmaleimide, phenol, adrenaline, theophylline, disodium cromoglycate, sucrose or excess sodium chloride. It was concluded that a similar mechanism was operative in histamine release by soluble immune complexes in unsensitized perfused guinea-pig lung and by antigen in passively sensitized lung.
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