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  • Title: Antigens in the spleen. The non-specificity of the follicles in the process of antigen trapping and the role of antibody.
    Author: van Rooijen N.
    Journal: Immunology; 1972 May; 22(5):757-65. PubMed ID: 4112177.
    Abstract:
    The localization of antigen in actively immunized rabbits was not different from that in passively immunized rabbits, confirming that trapping of antigen is antibody dependent. The sequence of events following a single antigen injection shows that the antigen trapping in the germinal centre cannot be responsible for either the germinal centre reaction or the initiation of the antibody production. It was established that two non-cross reacting antigens were trapped in the same spleen follicles if specific antibodies against both antigens were present in the circulation at the time of injection of the antigens.
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