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  • Title: Group-specific antigens of RNA tumor viruses as markers for subinfectious expression of the RNA virus genome.
    Author: Gilden RV, Oroszlan S.
    Journal: Proc Natl Acad Sci U S A; 1972 Apr; 69(4):1021-5. PubMed ID: 4112640.
    Abstract:
    Antigenic markers associated with the major internal protein of RNA tumor viruses of the C-type have proven extremely useful in natural history studies of these viruses. This protein possesses species-specific antigenic determinants, and, in the case of mammalian C-type viruses, the protein possesses crossreactive determinants as well. These determinants are, thus, useful for species identification and classification of mammalian viruses. A unique distribution of antigens in embryonic tissues of several species (where tests are available) was detected, and in addition, antigen expression in tissues appears to be controlled by a dominant gene. These data have contributed greatly to the theory that RNA tumor-virus information is inherited as part of the cellular genome.
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