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  • Title: Antigen-binding thymus-derived lymphocytes. II. Nature of the immunoglobulin determinants.
    Author: Hogg NM, Greaves MF.
    Journal: Immunology; 1972 Jun; 22(6):967-80. PubMed ID: 4113387.
    Abstract:
    Thymus-derived `rosette'-forming lymphocytes which have been separated from other SRBC-sensitive cells by means of cotton wool columns were examined for the presence of immunoglobulin. This was carried out by inhibition of rosette formation by anti-immunoglobulin sera. Inhibition was effected by a number of anti-IgM sera shown to contain antibodies with specificities directed towards the `hinge' region of the μ chain. No other heavy chain specific antisera were inhibitory. The ratio of rosette inhibition by anti-κ and anti-λ light chain sera varied during the course of the response to SRBC, the latter inhibiting by 89 per cent 3 days post-immunization.
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