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  • Title: Alpha heavy-chain disease in southern Iran.
    Author: Haghshenass M, Haghighi P, Abadi P, Kharazmi A, Gerami C, Nasr K.
    Journal: Am J Dig Dis; 1977 Oct; 22(10):866-73. PubMed ID: 411371.
    Abstract:
    A prospective study of 32 patients with primary upper small intestinal lymphoma in our region revealed 10 cases of alpha heavy-chain disease. Patients were mostly in the second and third decades of life and males predominated. Weight loss, diarrhea, and abdominal pain were the most common complaints and clubbing the most frequent physical findings. Laboratory tests revealed a malabsorption pattern on intestinal x-rays, and malabsorption of xylose, fat, and vitamin B12 was frequently noted. Dense plasmacytic infiltrate of the lamina propria of small bowel was the most frequent pathologic finding while true neoplasm of the lymphoid system (ie, immunoblastic sarcoma) was encountered in 20% of the cases.
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