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  • Title: Molecular relatedness of mammalian RNA tumor viruses as determined by DNA hybridization.
    Author: Haapala DK, Fischinger PJ.
    Journal: Science; 1973 Jun 01; 180(4089):972-4. PubMed ID: 4122422.
    Abstract:
    Each of six mammalian C-type viruses-including two feline leukemia viruses, three murine leukemia viruses, and the human "candidate" virus RD-114-can be distinguished from each other by hybridizing DNA synthesized by viral reverse transcriptase with viral RNA. Characterization of the DNA . RNA hybrids by hydroxylapatite chromatography revealed nucleotide sequence diversity among the viruses, detectable both by the amount of cross-hybridization and by the decreased thermal stability of heterologous hybrids.
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