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  • Title: The sheep immune response. Variation of anti-hapten and anti-carrier antibodies in the 1 and 2 immunoglobulin fractions.
    Author: Margni RA, Castrelos OD, Paz CB.
    Journal: Immunology; 1973 May; 24(5):781-9. PubMed ID: 4123676.
    Abstract:
    The results obtained in the quantification of γ1 and γ2 anti-hapten (DNP) and anti-carrier (HGG) antibodies obtained weekly during 50 weeks and proceeding from a group of three Merino sheep immunized with DNP—HGG, are described. The primary and secondary response and the antibody variations in weekly repeated stimulations were studied. The anti-DNP and anti-HGG total antibodies have similar variations. γ1 and γ2 anti-DNP and anti-HGG antibodies do not show differences in the primary response nor in weekly repeated stimulations. In the secondary response, a high increase of γ1 with loss of γ2 is observed. After a certain time γ1 decreases and γ2 increases.
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