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  • Title: Nephrotic syndrome--no evidence for a role for IgE.
    Author: Roy LP, Westberg NG, Michael AF.
    Journal: Clin Exp Immunol; 1973 Apr; 13(4):553-9. PubMed ID: 4123821.
    Abstract:
    It was not possible to demonstrate the presence of IgE in glomeruli of nineteen patients with the idiopathic nephrotic syndrome, using immunofluorescent techniques. Nine patients had minimal lesions, six were untreated; three had mesangial proliferation, all were untreated; seven had focal glomerular sclerosis, four were untreated. Occasional areas of smudgy positive staining were seen in glomeruli of six nephrotic patients with fluorescein-tagged goat anti-IgE but not with an immunologically identical, stronger rabbit anti-IgE. The pattern of staining and absorption studies indicated that this did not reflect the presence of IgE. Experience was similar with kidney biopsies from seventeen patients with a variety of renal diseases, including three with diffuse membranous nephropathy, and six patients who were kidney transplant donors. A mesangial pattern of staining for IgM and β1C globulin was present in seventeen of the nineteen biopsies from patients with nephrotic syndrome and either minimal changes or focal glomerular sclerosis.
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