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  • Title: Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine).
    Author: Pitha PM, Teich NM, Lowy DR, Pitha J.
    Journal: Proc Natl Acad Sci U S A; 1973 Apr; 70(4):1204-8. PubMed ID: 4123932.
    Abstract:
    Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The polymers were most effective as inhibitors when added during an early stage of virus replication. Effects of vinyl polymers on the RNA-dependent DNA polymerase from the virions of murine leukemia virus were also observed.
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