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  • Title: [Infrared spectrophotometry in quantitative drug analysis. II. Assay of some steroids].
    Author: Pawelczyk E, Pluta I, Marciniec B.
    Journal: Acta Pol Pharm; 1973; 30(3):289-95. PubMed ID: 4125361.
    Abstract:
    Infrared spectrometry was applied to the determination of mestranol, chlormadinone, estradiol benzoate, progesterone, testosterone propionate, and methyltestosterone. Except for mestranol, all of the steroids were determined in the range of 1656-1735 cm (-1) on the ground of the absorption of the carbonyl groups. Mestranol can be determined at 3308 cm (-1) (ethyl group variations) or at 1502 cm (-1) (variations of the aromatic ring system). The asorption band 1495 cm (-1) has been shown to be suitable for assaying estradiol benzoate. A relative error of .58% to 3.26% has been charged for the methods used. Methyltestosterone and progesterone can also be assayed by using the absorption bands reflecting the vibrations of the methyl groups, at 1361 cm (-1) and 1380 cm (-1). However, the assays at the latter wave lengths are found to be less accurate, with relative error at 3.49% and 4.41% and precision error at 1.19% and 1.39%, respectively. All measurements were performed in a medium of highly purified chloroform.
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