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  • Title: Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.
    Author: Shelburne JD, Arstila AU, Trump BF.
    Journal: Am J Pathol; 1973 Sep; 72(3):521-40. PubMed ID: 4125701.
    Abstract:
    Intraperitoneal injections of either cyclic AMP or dibutyryl cyclic AMP are capable of producing a wave of autophagy in rat liver which resembles closely that stimulated by glucagon. These autophagic vacuoles are acid-phosphatase-positive and appear to arise via the envelopment of organelles by double-walled cisterna. At later times these autophagic vacuoles are usually surrounded by a single membrane. Injection of equimolar amounts of 5'-AMP failed to produce a wave of autophagy. These findings constitute preliminary evidence that glucagon-stimulated autophagy is mediated at least in part by cyclic AMP.
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