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  • Title: Reticuloendothelial clearance studies in the course of horse serum induced nephritis.
    Author: Wardle EN.
    Journal: Br J Exp Pathol; 1974 Apr; 55(2):149-52. PubMed ID: 4134290.
    Abstract:
    Assessment of changes in activity of the reticuloendothelial system (RES), including the mesangial cells of the kidney, has been made by means of clearance studies of human aggregated gamma-globulin and of colloidal gold, during the course of horse serum sickness nephritis. RES blockade was found after protein loading and at the phase of circulating immune complexes. At other times RES activity was normal or increased. “Mesangial saturation” may have important implications for human nephritis.
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