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  • Title: Semisynthetic aminoglycoside antibacterials. 6. Synthesis of sisomicin, Antibiotic G-52, and novel 6'-substituted analogues of sisomicin from aminoglycoside 66-40C.
    Author: Davies DH, Mallams AK, Counelis M, Loebenberg D, Moss EL, Waitz JA.
    Journal: J Med Chem; 1978 Feb; 21(2):189-93. PubMed ID: 413921.
    Abstract:
    The discovery of aminoglycoside 66-40C, a novel dimeric, unsaturated imine produced by Micromonospora inyoensis, afforded a versatile intermediate for the synthesis of a variety of sisomicin analogues modified at the 6' position. The conversion of 66-40C into sisomicin, antibiotic G-52, and a series of novel 6'-substituted analogues of sisomicin is described, and the biological activity of the products is discussed.
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