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  • Title: Invluence of oral contraceptives on circulating immune response. II. Effect of progestogenic and estrogenic components.
    Author: Rangnekar KN, Rao SS, Joshi UM.
    Journal: Contraception; 1974 Nov; 10(5):527-33. PubMed ID: 4141295.
    Abstract:
    Female mice were treated with chlormadinone acetate (.25 mcg or 6.25 mcg), megestraol acetate (.25 mcg or 6.25 mcg), ethynodiol diacetate (.5 mcg or 12.5 mcg), norgestrel (.25 mcg or 6.25 mcg) or norethynodrel (2.5 mcg or 62.5 mcg) and studied to determine what effect these progestagens had on circulating tetanus antibody titers. None of the progesterones affected the immune response to tetanus toxoid. Mice given ethinyl estradiol or mestranol had enhanced circulating antibody titers. It is conlcuded that combination oral contraceptives act to diminish antibody response as a result of the combined potency of the estrogen and progesterone components.
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