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  • Title: Distribution of concanavalin a receptors on normal rat liver cells and zajdela ascites hepatoma cells.
    Author: Roth J.
    Journal: Int J Cancer; 1974 Dec 15; 14(6):762-70. PubMed ID: 4142787.
    Abstract:
    The distribution of Concanavalin A receptors in cultures of normal rat liver cells and of Zajdela ascites hepatoma cells of the rat was investigated by the Con A-po technique (Bernhard and Avrameas, 1971). Con A-po labelling of the cell surface showed a patchy distribution of Concanavalin A receptors in ascites hepatoma cells, whereas continuous Con A-po labelling was seen at the surface of normal rat liver cells. The different distribution of Concanavalin A receptors was caused by rapid internalization of Con A-po labelled material and not by a simple rearrangement of the receptors. The significance of this process is discussed with respect to Concanavalin A receptor mobility and membrane stability after cell transformation.
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