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  • Title: Osteomalacia after prolonged glutethimide administration.
    Author: Greenwood RH, Prunty FT, Silver J.
    Journal: Br Med J; 1973 Mar 17; 1(5854):643-5. PubMed ID: 4144245.
    Abstract:
    Vitamin D deficiency is a previously unreported complication of therapy with hypnotics, and we here report a case of osteomalacia associated with long-term glutethimide administration. There was evidence of pronounced hepatic enzyme induction, and the plasma half-time of (3)H vitamin D(3) was decreased by this drug. In addition, raised levels of serum gamma-glutamyl transpeptidase, 5-nucleotidase, and leucine aminopeptidase were observed and the patient excreted large amounts of xylulose. These changes were reversed by stopping the glutethimide.
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