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  • Title: Morphologic effects of thio-TEPA on mouse urothelium.
    Author: Murphy WM, Soloway MS, Lin CJ.
    Journal: Acta Cytol; 1977; 21(5):701-4. PubMed ID: 414498.
    Abstract:
    The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do no emanate from normal urothelium.
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