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  • Title: Metabolic response to isologous transplantation of small numbers of isolated islets of Langerhans in the rat.
    Author: Henriksson C, Bergmark J, Claes G.
    Journal: Eur Surg Res; 1977; 9(6):411-8. PubMed ID: 414921.
    Abstract:
    Pancreatic islets from adult donors were transplanted intraportally into 32 inbred, adult AGUS rats with streptozotocin diabetes. The islets were isolated with collagenase and counted individually. A relationship between the number of islets transplanted and the metabolic response could be demonstrated. Transplantation of less than 200 islets did not change the diabetic state. Rats receiving 200-220 improved, while recipients of 240-800 islets all exhibited normal values of blood glucose, plasma insulin, urine volume and urine glucose. The glucose tolerance, however, remained abnormal in all animals.
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