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  • Title: Histamine H2-receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves.
    Author: Eyre P, Wells PW.
    Journal: Br J Pharmacol; 1973 Oct; 49(2):364-7. PubMed ID: 4152252.
    Abstract:
    Depressor changes in carotid blood pressure caused by histamine or anaphylaxis in calves, were incompletely blocked by the H(1)-receptor antagonist mepyramine. Burimamide, the selective histamine H(2)-receptor antagonist, potentiated the depressor actions of histamine and anaphylaxis. Potentiated depressor responses were inhibited by mepyramine. Observations are consistent with histamine stimulating both H(1)- and H(2)-receptors to cause respectively vasodilatation and vasoconstriction.
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