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  • Title: The inhibitory effect of Ritodrine on human tubal activity in vivo.
    Author: Coutinho EM, Maia H, Filho JA.
    Journal: Fertil Steril; 1974 Jul; 25(7):596-601. PubMed ID: 4152294.
    Abstract:
    The effect of Ritodrine (4-hydroxy alpha-1-2-4-hydroxyphenyl ethylamino acetylbenzyl alcohol hydrochloride) on fallopian tubal activity was studied in 26 women of reproductive age who underwent abdominal surgery for tuboplasty (8 women), tubal ligation (6 women), or ovarian or uterine pathology (12 women). Tubal mobility was recorded by the intratubal microballoon method. Ritodrine was given intravenously at infusion rates of 50-600 mcg/minute or orally. At infusion rates of 200-300 mcg/minute, Ritodrine suppressed the spontaneous outbursts of increased activity, but tubal quiescence was achieved only at infusion rates of 400 mcg/minute or higher. Oral administration of 5-10 mg of Ritodrine was insufficient to depress motility, however 15-20 mg achieved quiescence lasting longer than 1 hour. It was suggested that it is conceivable that the administration of a beta-adrenergic activator such as Ritodrine at appropriate times of the menstrual cycle would interfere with conception through inhibition of the ovum retention mechanism in the tube.
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