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  • Title: [Role of the liver in lipid metabolism in the parenteral feeding of fatty emulsions].
    Author: Astvatsatur'ian AT, Cherkasov AI, Alimova EK.
    Journal: Vopr Pitan; 1978; (1):15-20. PubMed ID: 415433.
    Abstract:
    Tests conducted on dogs furnished information on the participation of the liver in the metabolism of heptadecanoic acid and fat emulsion "Intralipid-20%" with two modes of their administration: into the systemic circulation (through. v. jugularis) and directly into v. portal. Heptadecanoic acid is shown to undergo a whole series of transformations in the liver, in particular, it is very quickly and in fairly large amounts becomes incoporated in the structure of the molecular lipids forms, secreted into the blood as lipoproteins. Data derived from comparative investigations of a long-term infusion of "intralipid-20%" into the blood (19 days) and its effect on the lipids of diverse tissues showed that with the preparation introduced into v. portal and into the systemic circulation there is apparent a certain difference in the lipids metabolism rate.
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