These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Activity of the reticuloendothelial system and the antibody response. III. The fate of type III pneumococcal polysaccharide and the antibody response.
    Author: Sljivić VS, Warr GW.
    Journal: Immunology; 1974 Dec; 27(6):1009-22. PubMed ID: 4156026.
    Abstract:
    Pretreatment of mice with stilboestrol was shown to reduce the splenic direct PFC response to low, but not to high, immunizing doses of SIII. The fate of 125I-labelled SIII in control and stilboestrol-treated mice over a period of 3 weeks was observed. Stilboestrol-treated mice showed enhanced rate of clearance from the blood and hepatic uptake of 125I-labelled SIII, and a consistently depressed level of circulating 125I-labelled SIII. No consistent differences in splenic uptake of SIII between control and stilboestrol-treated mice were observed, but the excretion of radioactivity appeared to be slower in the latter group. The altered pattern of blood clearance and liver uptake of SIII in stilboestrol-treated mice is consistent with the potent stimulation of RES phagocytic activity induced by this agent, and it is suggested that the increased sequestration of SIII in stilboestrol-treated mice may be related to the observed effects of stilboestrol on the antibody response to this antigen.
    [Abstract] [Full Text] [Related] [New Search]